2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione

Base Information

• Chemical Name: 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione
• CAS No.: 1352051-26-3
• Molecular Formula: C₁₂H₁₄O₄S₂
• Molecular Weight: 286.373
• Mol file: 1352051-26-3.mol

Synonyms:2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione

Chemical Property of 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione

There total 2 articles about 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

acetylacetone (123-54-6,81235-32-7) + 4-(methylsulfanyl)benzenesulfonyl chloride (1129-25-5) → 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione (1352051-26-3)

Guidance literature:

acetylacetone; With sodium methylate; at 50 ℃; for 1h;

4-(methylsulfanyl)benzenesulfonyl chloride; In toluene; at 100 ℃;

DOI:10.5012/jkcs.2011.55.4.638

Reference yield:

methyl-phenyl-thioether (100-68-5) → 2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione (1352051-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chlorosulfonic acid

2.1: sodium methylate / 1 h / 50 °C

2.2: 100 °C

With chlorosulfonic acid; sodium methylate;

DOI:10.5012/jkcs.2011.55.4.638

Reference yield: 76.0%

2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione (1352051-26-3) + ethylenediamine (107-15-3,85404-18-8) → 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine (1352051-27-4)

Guidance literature:

With silica sulfuric acid; In ethyl acetate; at 50 ℃; for 2h;

DOI:10.5012/jkcs.2011.55.4.638

upstream raw materials:

methyl-phenyl-thioether

acetylacetone

4-(methylsulfanyl)benzenesulfonyl chloride

Downstream raw materials:

6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine

3-[(4-methylthio)benzenesulfonyl]-2,4-dimethyl-3H-1,5-benzodiazepine