6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine

Base Information

• Chemical Name: 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine
• CAS No.: 1352051-27-4
• Molecular Formula: C₁₄H₁₈N₂O₂S₂
• Molecular Weight: 310.441
• Mol file: 1352051-27-4.mol

Synonyms:6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine

Chemical Property of 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine

There total 3 articles about 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione (1352051-26-3) + ethylenediamine (107-15-3,85404-18-8) → 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine (1352051-27-4)

Guidance literature:

With silica sulfuric acid; In ethyl acetate; at 50 ℃; for 2h;

DOI:10.5012/jkcs.2011.55.4.638

Reference yield:

4-(methylsulfanyl)benzenesulfonyl chloride (1129-25-5) → 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine (1352051-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / 1 h / 50 °C

1.2: 100 °C

2.1: silica sulfuric acid / ethyl acetate / 2 h / 50 °C

With sodium methylate; In ethyl acetate;

DOI:10.5012/jkcs.2011.55.4.638

Reference yield:

methyl-phenyl-thioether (100-68-5) → 6-[(4-methylthio)benzenesulfonyl]-5,7-dimethyl-2,3-dihydro-1H-1,4-diazepine (1352051-27-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chlorosulfonic acid

2.1: sodium methylate / 1 h / 50 °C

2.2: 100 °C

3.1: silica sulfuric acid / ethyl acetate / 2 h / 50 °C

With chlorosulfonic acid; sodium methylate; In ethyl acetate;

DOI:10.5012/jkcs.2011.55.4.638

upstream raw materials:

2-[(4-methylthio)benzenesulfonyl]-1,3-dimethylpropane-1,3-dione

ethylenediamine

methyl-phenyl-thioether

4-(methylsulfanyl)benzenesulfonyl chloride