ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS No.:134266-22-1
Molecular Formula:C₁₅H₁₇BrN₂O₅
Molecular Weight:385.214
Hs Code.:
Mol file:134266-22-1.mol

Synonyms:ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property:

Boiling Point:463.1±45.0 °C(Predicted)
PKA:8.34±0.40(Predicted)
Density:1.474±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 2 articles about ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 134266-22-1
ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: In neat (no solvent); for 0.25h; Microwave irradiation; Green chemistry;
DOI:10.1080/15421406.2016.1235928

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 134266-22-1
ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 0 - 5 °C

2: neat (no solvent) / 0.25 h / Microwave irradiation; Green chemistry

With bromine; acetic acid; In neat (no solvent); 2: |Biginelli Pyrimidone Synthesis;
DOI:10.1080/15421406.2016.1235928