1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

Base Information

Chemical Name:1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene
CAS No.:215715-46-1
Molecular Formula:C₂₄H₂₇IO₆
Molecular Weight:538.379
Hs Code.:

Synonyms:1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

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Chemical Property of 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

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Technology Process of 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

There total 8 articles about 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 64-69-7
Iodoacetic acid

: 215715-45-0
5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol

: 215715-46-1
1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In hexane; dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0968-0896(02)00237-7

Reference yield:

: 621-59-0
isovanillin

: 215715-46-1
1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 95 percent / silver trifluoroacetate; iodine / CH₂Cl₂ / 12 h / Heating

3: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

4: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

5: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

6: 90 percent / DMAP; DCC / CH₂Cl₂; hexane / 5 h / 20 °C

With dmap; copper(l) iodide; ammonia; iodine; silver trifluoroacetate; potassium carbonate; potassium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00237-7

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 215715-46-1
1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / silver trifluoroacetate; iodine / CH₂Cl₂ / 12 h / Heating

2: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

3: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

4: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

5: 90 percent / DMAP; DCC / CH₂Cl₂; hexane / 5 h / 20 °C

With dmap; copper(l) iodide; ammonia; iodine; silver trifluoroacetate; potassium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; hexane; dichloromethane;
DOI:10.1016/S0968-0896(02)00237-7