Technology Process of 3,5-Bis-benzyloxy-4-[1-(2-benzyloxy-6-benzyloxycarbonyl-phenyl)-vinyl]-benzoic acid benzyl ester
There total 11 articles about 3,5-Bis-benzyloxy-4-[1-(2-benzyloxy-6-benzyloxycarbonyl-phenyl)-vinyl]-benzoic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-Benzyloxy-5-(3-benzyloxy-2-vinyl-benzoyloxy)-4-iodo-benzoic acid benzyl ester;
With
bis-triphenylphosphine-palladium(II) chloride; sodium acetate;
In
N,N-dimethyl-formamide; acetonitrile;
at 85 ℃;
for 43h;
benzyl bromide;
With
potassium hydroxide;
In
acetonitrile;
for 16.5h;
DOI:10.1016/S0040-4020(02)00096-0
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: K2CO3 / dimethylformamide
2.1: LiOH; H2O / tetrahydrofuran
3.1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h
4.1: 100 percent / Et3N / CH2Cl2 / 6.5 h
5.1: 86 percent / Ph3P; C2Cl6; Et3N / acetonitrile / 0.75 h
6.1: 100 percent / tetrahydrofuran / 18.5 h / 25 °C
7.1: 39 mg / aq. NaOH / methanol / 96 h / Heating
8.1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h
9.1: 462 mg / Et3N / CH2Cl2 / 17 h
10.1: (Ph3P)2PdCl2; NaOAc / acetonitrile; dimethylformamide / 43 h / 85 °C
10.2: 83 percent / KOH / acetonitrile / 16.5 h
With
bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium hydroxide; oxalyl dichloride; hexachloroethane; water; sodium acetate; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(02)00096-0
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h
2.1: 100 percent / Et3N / CH2Cl2 / 6.5 h
3.1: 86 percent / Ph3P; C2Cl6; Et3N / acetonitrile / 0.75 h
4.1: 100 percent / tetrahydrofuran / 18.5 h / 25 °C
5.1: 39 mg / aq. NaOH / methanol / 96 h / Heating
6.1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h
7.1: 462 mg / Et3N / CH2Cl2 / 17 h
8.1: (Ph3P)2PdCl2; NaOAc / acetonitrile; dimethylformamide / 43 h / 85 °C
8.2: 83 percent / KOH / acetonitrile / 16.5 h
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; oxalyl dichloride; hexachloroethane; sodium acetate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(02)00096-0
