2-(phenyl-d5)pyridine

Base Information

• Chemical Name: 2-(phenyl-d5)pyridine
• CAS No.: 105664-48-0
• Molecular Formula: C₁₁H₉N
• Molecular Weight: 160.159
• Mol file: 105664-48-0.mol

Synonyms:2-(phenyl-d5)pyridine

Chemical Property of 2-(phenyl-d5)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(phenyl-d5)pyridine

There total 16 articles about 2-(phenyl-d5)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-pyridine (109-04-6) + 2,3,4,5,6-pentadeuteriumbenzeneboronic acid (215527-70-1) → 2-(phenyl-d5)pyridine (105664-48-0)

Guidance literature:

With palladium diacetate; potassium carbonate; In ethanol; water; at 80 ℃; for 1h;

DOI:10.1039/d1gc03187b

Reference yield: 96.0%

2-chloropyridine (109-09-1) + bromobenzene-d5 (4165-57-5) → 2-(phenyl-d5)pyridine (105664-48-0)

Guidance literature:

bromobenzene-d5; With magnesium; In tetrahydrofuran; at 20 - 65 ℃; for 2h;

2-chloropyridine; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 11h;

DOI:10.1021/ol8011875

Reference yield: 92.0%

2-bromo-pyridine (109-04-6) + C8H6(2)H5BO2 (525598-50-9) → 2-(phenyl-d5)pyridine (105664-48-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 20h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/jacs.8b09095

upstream raw materials:

benzene-d6

sodium 2-pyridine diazotate

acetic acid

pyridine N-oxide

Downstream raw materials:

2-(4'-tert-butyl-3,4,5,6-tetradeuteriobiphenyl-2-yl)pyridine

4,4'-di-tert-butylbiphenyl

C₁₇H₁₄⁽²⁾H₃N

C₁₇H₁₃⁽²⁾H₄N