(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

Base Information

Chemical Name:(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate
CAS No.:1438424-45-3
Molecular Formula:C₃₀H₂₈N₈O₂
Molecular Weight:532.605
Hs Code.:

Synonyms:(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

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Chemical Property of (R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

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Technology Process of (R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

There total 3 articles about (R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69491-56-1
3-(pyrimidin-2-yl)aniline

: 1438424-13-5
(R)-benzyl-1-((6-chloro-5-cyanopyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

: 1438424-45-3
(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

Guidance literature:: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 95 ℃; for 2h;

Reference yield:

: (R)-benzyl 1-(amino(cyclopropyl)methyl)cyclopropylcarbamate HCl salt

: 1438424-45-3
(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 2 h / 95 °C

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;

Reference yield:

: 313339-92-3
3,5-dichloro-pyrazine-2-carbonitrile

: 1438424-45-3
(R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 2 h / 95 °C

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;