benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate

Base Information

• Chemical Name: benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate
• CAS No.: 148255-76-9
• Molecular Formula: C₂₈H₂₇NO₅
• Molecular Weight: 457.526
• Mol file: 148255-76-9.mol

Synonyms:benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate

Chemical Property of benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate

There total 4 articles about benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

benzyl bromide (100-39-0) + 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid (148254-72-2) → benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate (148255-76-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1248/cpb.47.481

Reference yield:

4-indol-3-yl-butyric acid (133-32-4) → benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate (148255-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, from -45 deg C to 0 deg C, 2.) DMF, -20 deg C, 30 min

2: 96.9 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.481

Reference yield:

4-(methoxymethoxy)benzoic acid (25458-44-0) → benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate (148255-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 25 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 15 h / Heating

2: 1.) NaH / 1.) DMF, from -45 deg C to 0 deg C, 2.) DMF, -20 deg C, 30 min

3: 96.9 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

With sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.481

upstream raw materials:

benzyl bromide

4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid

4-indol-3-yl-butyric acid

4-(methoxymethoxy)benzoic acid

Downstream raw materials:

benzyl 4-<1-(4-hydroxybenzoyl)-1H-indol-3-yl>butyrate