(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

Base Information

Chemical Name:(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone
CAS No.:1196550-66-9
Molecular Formula:C₂₇H₂₈FN₇O₂
Molecular Weight:501.563
Hs Code.:

Synonyms:(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

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Chemical Property of (R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

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Technology Process of (R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

There total 6 articles about (R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (R)-2-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-oxoethyl acetate

: 1196550-66-9
(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

Guidance literature:: With potassium carbonate; In methanol; at 60 ℃; for 0.0833333h;
DOI:10.1021/acsmedchemlett.5b00050

Reference yield:

: 1365212-61-8
(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

: 1196550-66-9
(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 110 °C

3: potassium carbonate / methanol / 0.08 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/acsmedchemlett.5b00050

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 1196550-66-9
(R)-1-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

2: potassium fluoride / dimethyl sulfoxide / 72 h / 100 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

4: dimethyl sulfoxide / 2 h / 110 °C

5: potassium carbonate / methanol / 0.08 h / 60 °C

With potassium fluoride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acsmedchemlett.5b00050