(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Base Information

Chemical Name:(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol
CAS No.:885621-52-3
Molecular Formula:C₂₃H₂₆F₂O₆
Molecular Weight:436.453
Hs Code.:

Synonyms:(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Suppliers and Price of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

There total 4 articles about (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98-88-4
benzoyl chloride

: 634181-80-9
(2R,3R,5S)-3-O-benzyl-4,4-difluoro-1,2-O-isopropylidenehexane-1,2,3,5,6-pentol

: 885621-52-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Guidance literature:: With pyridine; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo052652h

Reference yield:

: 100-39-0
benzyl bromide

: 885621-52-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Guidance literature:: Multi-step reaction with 3 steps

1: 78.5 percent / NaH; TBAI / tetrahydrofuran

2: OsO₄; NMNO / acetone; H₂O

3: 90 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1021/jo052652h

Reference yield:

: 634181-78-5
(R)-4-((R)-1-(benzyloxy)-2,2-difluorobut-3-en-1-yl)-2,2-dimethyl-1,3-dioxolane

: 885621-52-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

Guidance literature:: Multi-step reaction with 2 steps

1: OsO₄; NMNO / acetone; H₂O

2: 90 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; In dichloromethane; water; acetone;
DOI:10.1021/jo052652h