1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

Base Information

Chemical Name:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea
CAS No.:1402581-63-8
Molecular Formula:C₂₂H₂₁ClF₄N₄O₃
Molecular Weight:500.88
Hs Code.:

Synonyms:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

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Chemical Property of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

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Technology Process of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

There total 6 articles about 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1419602-48-4
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

: 1402585-94-7
phenyl 4-(1,3-dihydroxy-2-methylpropan-2-yl)-3-fluorophenylcarbamate

: 1402581-63-8
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1402581-63-8
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

1.2: 5 h / 50 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 23 °C

3.1: methanol; sodium tetrahydroborate / 16 h / 0 - 23 °C

4.1: hydrogen; palladium 10% on activated carbon / ethanol / 3 h / 23 °C

5.1: pyridine / acetone / 1 h / 0 - 23 °C

6.1: triethylamine / N,N-dimethyl-formamide / 16 h / 50 °C

With pyridine; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 188975-47-5
dimethyl 2-(2-fluoro-4-nitrophenyl)malonate

: 1402581-63-8
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 23 °C

2: methanol; sodium tetrahydroborate / 16 h / 0 - 23 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 3 h / 23 °C

4: pyridine / acetone / 1 h / 0 - 23 °C

5: triethylamine / N,N-dimethyl-formamide / 16 h / 50 °C

With pyridine; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetone;