(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

Base Information

Chemical Name:(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate
CAS No.:1381762-47-5
Molecular Formula:C₂₁H₂₇N₃O₇S₂
Molecular Weight:497.593
Hs Code.:

Synonyms:(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

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Technology Process of (S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

There total 2 articles about (S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1381762-41-9
(S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-(1-tosyl-1H-imidazol-4-yl)propan-2-yl)carbamate

: 2365-48-2
Methyl thioglycolate

: 1381762-47-5
(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/psc.2483

Reference yield:

: 35899-43-5
Boc-His(Tos)-OH

: 1381762-47-5
(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-(1-tosyl-1H-imidazol-4-yl)propanoyl)thio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 50 °C / Irradiation

2: triethylamine / tetrahydrofuran / 2 h / 20 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/psc.2483