(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Base Information

Chemical Name:(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester
CAS No.:778557-15-6
Molecular Formula:C₂₁H₂₉N₃O₈
Molecular Weight:451.477
Hs Code.:

Synonyms:(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

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Chemical Property of (R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

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Technology Process of (R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

There total 9 articles about (R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 182748-75-0
(R)-2-{2-[((R)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

: 778557-15-6
(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1016/0040-4039(96)01515-8

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 778557-15-6
(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether

2: HCl

3: 92 percent / activating agent

4: 89 percent / HCl / ethyl acetate

With hydrogenchloride; In diethyl ether; ethyl acetate;
DOI:10.1016/0040-4039(96)01515-8

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 778557-15-6
(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether

2: H₂ / catalytic hydrogenolysis

3: tetrahydrofuran; dimethylformamide / carboxy activation

4: H₂

5: 92 percent / activating agent

6: 89 percent / HCl / ethyl acetate

With hydrogenchloride; hydrogen; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01515-8