C₃₈H₄₀N₄O₁₄

Base Information

• Chemical Name: C₃₈H₄₀N₄O₁₄
• CAS No.: 130867-65-1
• Molecular Formula: C₃₈H₄₀N₄O₁₄
• Molecular Weight: 776.754
• Mol file: 130867-65-1.mol

Synonyms:C₃₈H₄₀N₄O₁₄

Chemical Property of C₃₈H₄₀N₄O₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₄₀N₄O₁₄

There total 10 articles about C₃₈H₄₀N₄O₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C43H46N4O16 (133510-55-1) → C38H40N4O14 (130867-65-1)

Guidance literature:

With acetic acid; hydrazine; In pyridine; ethyl acetate; for 0.0166667h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86429-2

Reference yield:

benzoyl chloride (98-88-4) → C38H40N4O14 (130867-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-diisopropylethylamine (DIPEA) / pyridine / 1 h / Ambient temperature

2: 85 percent / 90percent aq. acetic acid / 0.5 h / 50 °C

3: 44 percent / N-iodosuccinimide (NIS), molecular sieves (5 Angstroem) / TfOH / 1,2-dichloro-ethane; diethyl ether / 0.17 h / 0 °C

4: 78 percent / hydrazine, acetic acid / pyridine; ethyl acetate / 0.02 h / Ambient temperature

With N-iodo-succinimide; 5A molecular sieve; acetic acid; N-ethyl-N,N-diisopropylamine; hydrazine; trifluorormethanesulfonic acid; In pyridine; diethyl ether; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4020(01)86429-2

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C38H40N4O14 (130867-65-1)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 2 h / 20 °C

2: N,N-diisopropylethylamine (DIPEA) / pyridine / 1 h / Ambient temperature

3: 85 percent / 90percent aq. acetic acid / 0.5 h / 50 °C

4: 44 percent / N-iodosuccinimide (NIS), molecular sieves (5 Angstroem) / TfOH / 1,2-dichloro-ethane; diethyl ether / 0.17 h / 0 °C

5: 78 percent / hydrazine, acetic acid / pyridine; ethyl acetate / 0.02 h / Ambient temperature

With pyridine; N-iodo-succinimide; 5A molecular sieve; acetic acid; N-ethyl-N,N-diisopropylamine; hydrazine; trifluorormethanesulfonic acid; In pyridine; diethyl ether; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4020(01)86429-2

upstream raw materials:

C₄₃H₄₆N₄O₁₆

4-pentenyloxymethylchloride

3'-O-methoxyacetyl-N³-benzoyl-thymidine

5'-O-(4-4'-dimethoxytrityl)-N³-benzoyl thymidine

Downstream raw materials:

C₇₇H₇₆N₆O₂₂

C₆₁H₆₄N₆O₂₂