(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one
CAS No.:1130247-01-6
Molecular Formula:C₃₄H₃₈FNO₇
Molecular Weight:591.677
Hs Code.:

Synonyms:(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

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Chemical Property of (3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

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Technology Process of (3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

There total 5 articles about (3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4926-12-9
4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione

: 1130246-56-8
(4S)-5,5-di(2-methoxy-5-methylphenyl)-4-isopropyloxazolidin-2-one

: 1130247-01-6
(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: (4S)-5,5-di(2-methoxy-5-methylphenyl)-4-isopropyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -78 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.08.001

Reference yield:

: C₁₂H₁₂ClFO₃

: 1130246-56-8
(4S)-5,5-di(2-methoxy-5-methylphenyl)-4-isopropyloxazolidin-2-one

: 1130247-01-6
(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: (4S)-5,5-di(2-methoxy-5-methylphenyl)-4-isopropyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₂H₁₂ClFO₃; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2008.12.010

Reference yield:

: 52927-40-9
dimethyl 2-(4-fluorobenzylidene)malonate

: 1130247-01-6
(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 72 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol; water / Reflux; Inert atmosphere

3.1: sulfuric acid / water / 6 h / Inert atmosphere; Reflux

4.1: acetic anhydride / 2.5 h / 100 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

5.2: 4 h / -78 °C / Inert atmosphere

With n-butyllithium; sulfuric acid; sodium methylate; acetic anhydride; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; water; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.tetasy.2012.08.001