(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

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Chemical Name:(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one
CAS No.:1407597-85-6
Molecular Formula:C₄₀H₄₃FN₂O₆
Molecular Weight:666.79
Hs Code.:

Synonyms:(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

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Chemical Property of (3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

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Technology Process of (3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

There total 7 articles about (3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1130247-01-6
(3'R,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-methoxycarbonyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

: 100-46-9
benzylamine

: 1407597-85-6
(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.08.001

Reference yield:

: 52927-40-9
dimethyl 2-(4-fluorobenzylidene)malonate

: 1407597-85-6
(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 72 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol; water / Reflux; Inert atmosphere

3.1: sulfuric acid / water / 6 h / Inert atmosphere; Reflux

4.1: acetic anhydride / 2.5 h / 100 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

5.2: 4 h / -78 °C / Inert atmosphere

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; sulfuric acid; sodium methylate; acetic anhydride; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.tetasy.2012.08.001

Reference yield:

: 3449-63-6
3-(4-fluorophenyl)pentan-1,5-dioic acid

: 1407597-85-6
(3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / 2.5 h / 100 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; acetic anhydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2012.08.001