6-methoxy-1-naphthylbenzyl ketone

Base Information

• Chemical Name: 6-methoxy-1-naphthylbenzyl ketone
• CAS No.: 69769-77-3
• Molecular Formula: C₁₉H₁₆O₂
• Molecular Weight: 276.335
• Mol file: 69769-77-3.mol

Synonyms:6-methoxy-1-naphthylbenzyl ketone

Chemical Property of 6-methoxy-1-naphthylbenzyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 6-methoxy-1-naphthylbenzyl ketone

There total 5 articles about 6-methoxy-1-naphthylbenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

4,6-dimethoxy-1-naphthylbenzyl ketone (69769-74-0) → 6-methoxy-1-naphthol (22604-07-5) + 6-methoxy-1-naphthylbenzyl ketone (69769-77-3) + 6-methoxy-1-naphthoic acid (36112-61-5) + 1-(6-Methoxy-naphthalen-1-yl)-2-phenyl-ethane-1,2-dione (69769-79-5) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With ammonium chloride; sodium; In ethanol; ammonia; for 4h; Product distribution; Variation of the cosolvent: Et₂O or THF;

DOI:10.1016/S0040-4020(01)98894-5

Reference yield:

1,7-dimethoxynaphthalene (5309-18-2) → 6-methoxy-1-naphthylbenzyl ketone (69769-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / AlCl₃ (anhydr.) / nitrobenzene / 16 h / Ambient temperature

2: 1.) Na metal, ammonium chloride, 2.) 15percent H₂O₂, 5percent NaOH / 1.) EtOH, THF, liq. NH₃, 4h, 2.) methanol

With sodium hydroxide; aluminium trichloride; ammonium chloride; dihydrogen peroxide; sodium; In nitrobenzene;

DOI:10.1016/S0040-4020(01)98894-5

Reference yield:

phenylacetyl chloride (103-80-0) → 6-methoxy-1-naphthylbenzyl ketone (69769-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / AlCl₃ (anhydr.) / nitrobenzene / 16 h / Ambient temperature

2: 1.) Na metal, ammonium chloride, 2.) 15percent H₂O₂, 5percent NaOH / 1.) EtOH, THF, liq. NH₃, 4h, 2.) methanol

With sodium hydroxide; aluminium trichloride; ammonium chloride; dihydrogen peroxide; sodium; In nitrobenzene;

DOI:10.1016/S0040-4020(01)98894-5

upstream raw materials:

4,6-dimethoxy-1-naphthylbenzyl ketone

1,7-dimethoxynaphthalene

phenylacetyl chloride