5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

Base Information

Chemical Name:5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate
CAS No.:1267850-93-0
Molecular Formula:CH₄O₃S*C₂₃H₂₈N₄O₃
Molecular Weight:504.607
Hs Code.:

Synonyms:5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

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Chemical Property of 5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

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Technology Process of 5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

There total 5 articles about 5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1267850-92-9
N-(5-tert-butylisoxazol-3-yl)-2-(4-(6-(2-methoxyethylamino)pyridin-3-yl)phenyl)acetamide

: 1267850-93-0
5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

Guidance literature:: In ethanol; at 60 ℃; for 2h;

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 1267850-93-0
5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 180 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; microwave reactor

3: ethanol / 2 h / 60 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 55809-36-4
3-amino-5-tert-butylisoxazole

: 1267850-93-0
5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-N-(2-methoxyethyl)pyridin-2-aminium methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 160 °C / Inert atmosphere; microwave reactor

3.1: ethanol / 2 h / 60 °C

With sodium carbonate; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;