1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine

Base Information

• Chemical Name: 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine
• CAS No.: 1116230-14-8
• Molecular Formula: C₁₅H₂₃N₃O₃
• Molecular Weight: 293.366
• Mol file: 1116230-14-8.mol

Synonyms:1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine

Chemical Property of 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine

There total 5 articles about 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(1-methylethyl)piperazine (4318-42-7) + 1-fluoro-5-methoxy-2-methyl-4-nitro-benzene (314298-13-0) → 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine (1116230-14-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 12h;

Reference yield: 41.0%

1-(5-methoxy-2-methyl-4-nitrophenyl)piperazine (1116230-01-3) + isopropyl bromide (75-26-3) → 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine (1116230-14-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-d₆-formamide; at 80 ℃; for 3h;

Reference yield:

1,5-dichloro-2-methyl-4-nitrobenzene (7149-77-1) → 1-isopropyl-4-(5-methoxy-2-methyl-4-nitrophenyl)piperazine (1116230-14-8)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / 3 h / 20 °C

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4: potassium carbonate / N,N-dimethyl-d₆-formamide / 3 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-d₆-formamide;

upstream raw materials:

1-(1-methylethyl)piperazine

1-fluoro-5-methoxy-2-methyl-4-nitro-benzene

1-(5-methoxy-2-methyl-4-nitrophenyl)piperazine

isopropyl bromide

Downstream raw materials:

4-(4-isopropylpiperazin-1-yl)-2-methoxy-5-methylaniline