2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol

Base Information

Chemical Name:2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol
CAS No.:330981-72-1
Molecular Formula:C₁₃H₁₄BrN₃O
Molecular Weight:308.178
Hs Code.:
DSSTox Substance ID:DTXSID90416373
Wikidata:Q27074518
Pharos Ligand ID:C3HH7L8GVBB6
ChEMBL ID:CHEMBL1956589
Mol file:330981-72-1.mol

Synonyms:2-(2-(4-bromophenyl)-6-methylpyrimidin-4-yl)aminoethanol;AS 1269574;AS-1269574;AS1269574

Suppliers and Price of 2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AS 1269574
10mg
$ 446.00

TRC
2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol
250mg
$ 1840.00

Tocris
AS1269574 ≥98%(HPLC)
10
$ 147.00

Tocris
AS1269574 ≥98%(HPLC)
50
$ 617.00

Matrix Scientific
2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol 95%
100mg
$ 1249.00

Matrix Scientific
2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol 95%
250mg
$ 2748.00

CSNpharm
AS1269574
50mg
$ 545.00

CSNpharm
AS1269574
10mg
$ 130.00

CSNpharm
AS1269574
250mg
$ 1575.00

ChemScene
AS1269574 98.76%
100mg
$ 600.00

Total 6 raw suppliers

Chemical Property of 2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol

Chemical Property:

Solubility.:Soluble in DMSO
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:307.03202
Heavy Atom Count:18
Complexity:246

Purity/Quality:

97% ^*data from raw suppliers

AS 1269574 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=NC(=N1)C2=CC=C(C=C2)Br)NCCO
Uses Acts as an orally available agonist of GPR119 (G-protein coupled receptor 119), a regulator of incretin and insulin hormone secretion.

Technology Process of 2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol

There total 4 articles about 2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 97513-47-8
2-(4-bromophenyl)-4-chloro-6-methylpyrimidine

: 141-43-5
ethanolamine

: 330981-72-1
A⁽⁶⁹⁵⁾S₁₂₇₄

Guidance literature:: 2-(4-bromophenyl)-4-chloro-6-methylpyrimidine; ethanolamine; In acetonitrile; at 70 - 85 ℃; for 20.5h;

With sodium hydroxide; In water;
DOI:10.1016/j.bmc.2012.02.006

Reference yield:

: 180606-52-4
2-(4-bromophenyl)-6-methylpyrimidin-4-one

: 330981-72-1
A⁽⁶⁹⁵⁾S₁₂₇₄

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / 80 °C

2: acetonitrile / 20.5 h / 70 - 85 °C

With trichlorophosphate; In acetonitrile;
DOI:10.1016/j.bmc.2012.02.006

Reference yield:

: 55368-42-8
4-bromobenzamidine hydrochloride

: 330981-72-1
A⁽⁶⁹⁵⁾S₁₂₇₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 0.17 h / 20 °C

1.2: 20 - 65 °C

2.1: trichlorophosphate / 2 h / 80 °C

3.1: acetonitrile / 20.5 h / 70 - 85 °C

With sodium methylate; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2012.02.006