180606-52-4 Usage
Classification
Pyrimidines
Contained elements
Bromine atom, phenyl group, and methyl group
Functionality
Reversible inhibitor of monoamine oxidase A (RIMA)
Mechanism of action
Increases levels of monoamine neurotransmitters (serotonin, dopamine, and norepinephrine) in the brain
Primary uses
Treatment of major depressive disorder and social anxiety disorder
Side effect profile
Favorable compared to older MAOIs
Administration
Orally as a tablet or capsule
Availability
Sold under various trade names in several countries
Check Digit Verification of cas no
The CAS Registry Mumber 180606-52-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,6,0 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 180606-52:
(8*1)+(7*8)+(6*0)+(5*6)+(4*0)+(3*6)+(2*5)+(1*2)=124
124 % 10 = 4
So 180606-52-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H9BrN2O/c1-7-6-10(15)14-11(13-7)8-2-4-9(12)5-3-8/h2-6H,1H3,(H,13,14,15)
180606-52-4Relevant articles and documents
Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists
Negoro, Kenji,Yonetoku, Yasuhiro,Maruyama, Tatsuya,Yoshida, Shigeru,Takeuchi, Makoto,Ohta, Mitsuaki
experimental part, p. 2369 - 2375 (2012/05/05)
Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.