8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

Base Information

Chemical Name:8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid
CAS No.:1428797-09-4
Molecular Formula:C₂₀H₁₇FN₂O₄
Molecular Weight:368.364
Hs Code.:

Synonyms:8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

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Chemical Property of 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

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Technology Process of 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

There total 12 articles about 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428797-08-3
methyl 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylate

: 1428797-09-4
8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

Guidance literature:: methyl 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylate; With water; potassium hydroxide; In tetrahydrofuran; methanol; at 60 ℃;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 6636-78-8
2-chloro-3-hydroxypyridine

: 1428797-09-4
8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / dimethyl sulfoxide / 50 °C

2.1: dimethyl sulfoxide / 80 °C

3.1: bromine; sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 °C

4.1: tetrabutyl ammonium fluoride / toluene / 110 °C

5.1: diborane / tetrahydrofuran / 2 h / Reflux

5.2: 0.5 h / 50 °C

6.1: bromine; sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 - 20 °C

7.1: di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine / tetrahydrofuran / 2 h / Reflux

8.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 120 °C

9.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 120 °C

10.1: water; potassium hydroxide / tetrahydrofuran; methanol / 60 °C

10.2: pH 2

With bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; bromine; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 52605-97-7
2,3-dimethoxypyridine

: 1428797-09-4
8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine; sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 °C

2.1: tetrabutyl ammonium fluoride / toluene / 110 °C

3.1: diborane / tetrahydrofuran / 2 h / Reflux

3.2: 0.5 h / 50 °C

4.1: bromine; sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 - 20 °C

5.1: di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine / tetrahydrofuran / 2 h / Reflux

6.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 120 °C

7.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 120 °C

8.1: water; potassium hydroxide / tetrahydrofuran; methanol / 60 °C

8.2: pH 2

With bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; bromine; palladium diacetate; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;