[(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol

Base Information

• Chemical Name: [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol
• CAS No.: 244260-87-5
• Molecular Formula: C₃₂H₄₀O₄Si
• Molecular Weight: 516.753

Synonyms:[(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol

Chemical Property of [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol

Chemical Property:

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Technology Process of [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol

There total 5 articles about [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S) methyl 2-([tert-butyl(diphenyl)silyloxy]methyl)-1-(4-methoxybenzyloxy)cyclohex-3-ene-1-carboxylate (244260-85-3) → [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol (244260-87-5)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃; for 2h;

DOI:10.1016/S0040-4039(99)00912-0

Reference yield:

(E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid methyl ester (244260-84-2) → [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol (244260-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Grubbs catalyst / CH₂Cl₂ / 0.5 h / Heating

2: DIBAH / CH₂Cl₂ / 2 h / -78 - 0 °C

With diisobutylaluminium hydride; Grubbs catalyst first generation; In dichloromethane;

DOI:10.1016/S0040-4039(99)00912-0

Reference yield:

(E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid → [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol (244260-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 0.5 h / Ambient temperature

2: Grubbs catalyst / CH₂Cl₂ / 0.5 h / Heating

3: DIBAH / CH₂Cl₂ / 2 h / -78 - 0 °C

With diisobutylaluminium hydride; Grubbs catalyst first generation; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(99)00912-0

upstream raw materials:

(1S,2S) methyl 2-([tert-butyl(diphenyl)silyloxy]methyl)-1-(4-methoxybenzyloxy)cyclohex-3-ene-1-carboxylate

(E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid methyl ester

Downstream raw materials:

2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

2,2-Dimethyl-propionic acid (1S,2R,3R,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-1-(4-methoxy-benzyloxy)-cyclohexylmethyl ester

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