2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester
CAS No.:244260-91-1
Molecular Formula:C₄₀H₅₄O₇Si
Molecular Weight:674.95
Hs Code.:

2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

There total 6 articles about 2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 77-76-9
2,2-dimethoxy-propane

: 244260-89-7
2,2-Dimethyl-propionic acid (1S,2R,3R,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-1-(4-methoxy-benzyloxy)-cyclohexylmethyl ester

: 244260-91-1
2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

Guidance literature:: With camphor-10-sulfonic acid; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4039(99)00912-0

Reference yield:

: (E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid

: 244260-91-1
2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 0.5 h / Ambient temperature

2: Grubbs catalyst / CH₂Cl₂ / 0.5 h / Heating

3: DIBAH / CH₂Cl₂ / 2 h / -78 - 0 °C

4: DMAP / pyridine / 20 h / 80 °C

5: OsO₄, NMO, MeSO₂NH₂ / 2-methyl-propan-2-ol; H₂O / 1.5 h / Ambient temperature

6: 85 percent / CSA / 0.5 h / Ambient temperature

With dmap; osmium(VIII) oxide; N-methyl-2-indolinone; methanesulfonamide; camphor-10-sulfonic acid; diisobutylaluminium hydride; Grubbs catalyst first generation; In pyridine; diethyl ether; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00912-0

Reference yield:

: 244260-84-2
(E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid methyl ester

: 244260-91-1
2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Grubbs catalyst / CH₂Cl₂ / 0.5 h / Heating

2: DIBAH / CH₂Cl₂ / 2 h / -78 - 0 °C

3: DMAP / pyridine / 20 h / 80 °C

4: OsO₄, NMO, MeSO₂NH₂ / 2-methyl-propan-2-ol; H₂O / 1.5 h / Ambient temperature

5: 85 percent / CSA / 0.5 h / Ambient temperature

With dmap; osmium(VIII) oxide; N-methyl-2-indolinone; methanesulfonamide; camphor-10-sulfonic acid; diisobutylaluminium hydride; Grubbs catalyst first generation; In pyridine; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00912-0