2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Base Information

Chemical Name:2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid
CAS No.:1044559-95-6
Molecular Formula:C₂₆H₂₉N₃O₇
Molecular Weight:495.532
Hs Code.:

Synonyms:2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Suppliers and Price of 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

There total 8 articles about 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1044559-92-3
2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

: 1044559-95-6
2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 1044559-95-6
2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / dichloromethane / 1.17 h / -10 °C

2: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

4: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

5: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 862259-02-7
trans-(3R,4R)-3,4-bis(methoxycarbonyl)cyclopentanol

: 1044559-95-6
2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(6-methoxy-2-phenyl-pyrimidin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium hydroxide; water / 4 h / 20 °C

1.3: 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 1.17 h / -10 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

5.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With methanol; triethylsilane; lithium hydroxide; sodium hydroxide; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;