N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

Base Information

Chemical Name:N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide
CAS No.:952674-73-6
Molecular Formula:C₁₉H₂₉N₃O₃
Molecular Weight:347.458
Hs Code.:

Synonyms:N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

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Technology Process of N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

There total 4 articles about N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 849351-33-3
N-{3-amino-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}acetamide

: 3282-30-2
pivaloyl chloride

: 952674-73-6
N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 849351-32-2
N-{3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}acetamide

: 952674-73-6
N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / 2068.65 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

Reference yield:

: 351-32-6
N-(4-fluoro-3-nitrophenyl)acetamide

: 952674-73-6
N-{5-(acetylamino)-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / Reflux

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / 2068.65 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate;