C₃₆H₄₅N₅O₅S

Base Information

• Chemical Name: C₃₆H₄₅N₅O₅S
• CAS No.: 1059608-90-0
• Molecular Formula: C₃₆H₄₅N₅O₅S
• Molecular Weight: 659.85
• Mol file: 1059608-90-0.mol

Synonyms:C₃₆H₄₅N₅O₅S

Chemical Property of C₃₆H₄₅N₅O₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₅N₅O₅S

There total 7 articles about C₃₆H₄₅N₅O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)- (959983-22-3) + octahydropyrrolo[1,2-a]pyrazine (5654-83-1) → C36H45N5O5S (1059608-90-0)

Guidance literature:

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.0333333h;

octahydropyrrolo[1,2-a]pyrazine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate (494799-19-8) → C36H45N5O5S (1059608-90-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 2 - 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.17 h / 22 - 50 °C

2.2: 21 - 24 h / 20 - 30 °C

3.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

3.2: 70 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

5.2: 0.5 h / 30 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.03 h

7.2: 14 h / 20 °C

With lithium hydroxide; sodium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

2-bromo-3-cyclohexyl-N-[(dimethylamino)sulfonyl]-1H-indole-6-carboxamide (902148-40-7) → C36H45N5O5S (1059608-90-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

1.2: 70 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

3.2: 0.5 h / 30 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.03 h

5.2: 14 h / 20 °C

With sodium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; HATU; lithium chloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-

octahydropyrrolo[1,2-a]pyrazine

methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid