5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

Base Information

Chemical Name:5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]
CAS No.:1448324-09-1
Molecular Formula:C₃₀H₃₆O₆
Molecular Weight:492.612
Hs Code.:

Synonyms:5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

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Chemical Property of 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

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Technology Process of 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

There total 4 articles about 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1448324-08-0
C₂₉H₃₃F₃O₉S

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1448324-09-1
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 19060-10-7
3,3-dimethoxypropanal

: 1448324-09-1
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - -55 °C / Inert atmosphere

2.1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); n-butyllithium; copper(II) bis(trifluoromethanesulfonate); bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; 3.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 1448324-07-9
5’-(5-hydroxy-7,7-dimethoxyhept-3-yn-2-yl)-2’,3’-dihydrospiro[1,3-dioxolane-2,1’-indene]-4’-yl trifluoromethanesulfonate

: 1448324-09-1
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

2: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); copper(II) bis(trifluoromethanesulfonate); bis[2-(diphenylphosphino)phenyl] ether; In N,N-dimethyl-formamide; toluene; 2: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078