5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

Base Information

Chemical Name:5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde
CAS No.:1448324-10-4
Molecular Formula:C₂₉H₃₄O₇
Molecular Weight:494.585
Hs Code.:

Synonyms:5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

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Chemical Property of 5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

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Technology Process of 5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

There total 5 articles about 5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1448324-09-1
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-4'-ethenyl-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]

: 1448324-10-4
5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

Guidance literature:: With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 19060-10-7
3,3-dimethoxypropanal

: 1448324-10-4
5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - -55 °C / Inert atmosphere

2.1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

4.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; n-butyllithium; copper(II) bis(trifluoromethanesulfonate); bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; toluene; 3.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 1448324-08-0
C₂₉H₃₃F₃O₉S

: 1448324-10-4
5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078