5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

Base Information

Chemical Name:5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole
CAS No.:1448324-12-6
Molecular Formula:C₄₁H₅₅NO₈Si
Molecular Weight:717.975
Hs Code.:

5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

Synonyms:5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

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Chemical Property of 5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

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Technology Process of 5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

There total 7 articles about 5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1448324-11-5
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

: 1448324-12-6
5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

Guidance literature:: With Dess-Martin periodane; In dichloromethane; Inert atmosphere; Cooling with ice;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 1448324-07-9
5’-(5-hydroxy-7,7-dimethoxyhept-3-yn-2-yl)-2’,3’-dihydrospiro[1,3-dioxolane-2,1’-indene]-4’-yl trifluoromethanesulfonate

: 1448324-12-6
5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

2.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

4.2: 0.33 h / -78 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / Inert atmosphere; Cooling with ice

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; tert.-butyl lithium; copper(II) bis(trifluoromethanesulfonate); Dess-Martin periodane; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; pentane; 2.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 19060-10-7
3,3-dimethoxypropanal

: 1448324-12-6
5-[(5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl)carbonyl]-2-[tris(propan-2-yl)silyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - -55 °C / Inert atmosphere

2.1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

4.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

5.2: 0.33 h / -78 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / Inert atmosphere; Cooling with ice

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; n-butyllithium; tert.-butyl lithium; copper(II) bis(trifluoromethanesulfonate); Dess-Martin periodane; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; pentane; 3.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078