5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

Base Information

Chemical Name:5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol
CAS No.:1448324-11-5
Molecular Formula:C₄₁H₅₇NO₈Si
Molecular Weight:719.991
Hs Code.:

5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

Synonyms:5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

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Chemical Property of 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

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Technology Process of 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

There total 6 articles about 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1448324-10-4
5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde

: 433332-27-5
2-[tris(propan-2-yl)silyl]-1,3-oxazole

: 1448324-11-5
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

Guidance literature:: 2-[tris(propan-2-yl)silyl]-1,3-oxazole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.166667h; Inert atmosphere;

5-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2,3-dihydrospiro[1,3-dioxolane-2,1-indene]-4-carbaldehyde; In tetrahydrofuran; pentane; at -78 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 19060-10-7
3,3-dimethoxypropanal

: 1448324-11-5
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - -55 °C / Inert atmosphere

2.1: copper(II) bis(trifluoromethanesulfonate) / toluene / 0.17 h / 20 °C / Inert atmosphere

3.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

4.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

5.2: 0.33 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; n-butyllithium; tert.-butyl lithium; copper(II) bis(trifluoromethanesulfonate); bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; toluene; pentane; 3.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078

Reference yield:

: 1448324-08-0
C₂₉H₃₃F₃O₉S

: 1448324-11-5
5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro bis(acetonitrile) palladium(II); bis[2-(diphenylphosphino)phenyl] ether / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

2.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 8 h / 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.33 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; dichloro bis(acetonitrile) palladium(II); sodium periodate; osmium(VIII) oxide; tert.-butyl lithium; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; pentane; 1.1: |Stille Cross Coupling;
DOI:10.1080/00397911.2012.737078