N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

Base Information

Chemical Name:N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide
CAS No.:928782-76-7
Molecular Formula:C₂₃H₁₇Cl₂F₃N₄O₃
Molecular Weight:525.314
Hs Code.:

Synonyms:N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

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Chemical Property of N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

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Technology Process of N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

There total 7 articles about N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 928782-76-7
N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

3.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

3.2: 1.5 h / 80 °C

4.1: ISOPROPYLAMIDE / 2 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

5.2: 0.17 h / 0 °C

With sodium acetate; sodium hydride; potassium carbonate; potassium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; water;

Reference yield:

: 928782-78-9
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

: 75-36-5
acetyl chloride

: 928782-76-7
N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

Guidance literature:: 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

acetyl chloride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 928782-76-7
N-acetyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(1-pyrazolyl) benzoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

2.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

2.2: 1.5 h / 80 °C

3.1: ISOPROPYLAMIDE / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

4.2: 0.17 h / 0 °C

With sodium acetate; sodium hydride; potassium hydrogencarbonate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; water;