84677-05-4

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester
• Synonyms: Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester;1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid methyl ester;methyl 1-{[(benzyloxy)carbonyl]amino}cyclopropane-1-carboxylate
• CAS NO: 84677-05-4
• Molecular Formula: C₁₃H₁₅NO₄
• Molecular Weight: 249.2625
• Mol File: 84677-05-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester(84677-05-4)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester(84677-05-4)

Safety Data

• Hazardous Substances Data: 84677-05-4(Hazardous Substances Data)

Usage

General Description

Cyclopropanecarboxylic acid, 1-[[(phenylMethoxy)carbonyl]aMino]-, Methyl ester is a chemical compound that is a methyl ester derivative of cyclopropanecarboxylic acid, containing a phenylMethoxy carbonyl and aMino functional group. It is commonly used in organic synthesis and pharmaceutical research, particularly in the development of new drug compounds. Its unique chemical structure and properties make it a valuable building block for the synthesis of various bioactive molecules and pharmaceutical intermediates. This chemical compound plays a crucial role in the development of new pharmaceutical drugs and therapeutic agents.

Upstream product

• 76338-91-5 2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 15159-67-8 (2S)-2-benzyloxycarbonylamino-4-bromo-butyric acid methyl ester 
• 100-39-0 benzyl bromide 
• 501-53-1 benzyl chloroformate 
• 72784-42-0 methyl 1-aminocyclopropane-1-carboxylate hydrochloride 

Downstream Products

• 119111-66-9 1-methylamino-cyclopropanecarboxylic acid methyl ester 
• 210576-30-0 Methyl 1-(N-benzyloxycarbonyl-N-methyl)aminocyclopropane-1-carboxylic acid 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 

Relevant articles and documents

The synthesis of α,α-disubstituted α-amino acids via ichikawa rearrangement

An approach to α,α-disubstituted α-amino acids is reported. The key step is allyl cyanate-to-isocyanate rearrangement. As demonstrated, the resultant allyl isocyanates can be directly trapped with various nucleophiles, for instance, alcohols, amines, and organometallic reagents, to provide a broad range of N-functionalized allylamines. The developed method has been successfully applied in the synthesis of two bioactive peptides: 2-aminoadamantane-2-carboxylic acid derived P2X7-evoked glutamate release inhibitor and 4-amino-tetrahydropyranyl-4-carboxylic acid derived dipeptide GSK-2793660, which is currently in clinical trials as cathepsin C inhibitor for the treatment of cystic fibrosis, noncystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.

1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor

Several 1-aminocyclopropane-1-carboxylic acid derivatives were prepared and tested for activity at the glycine-binding site of the N-methyl-D- aspartate (NMDA) receptor complex. Structural modifications involved the amino group, the carboxylic function or

A Simple Synthesis of 1-Aminocyclopropane-1-carboxylic Acid

Conversion of N-carbobenzyloxy-L-glutamic acid α-methylester (Z-L-glu(OH)OCH3, 1) into the bromo derivative 2 and subsequent γ-elimination by the use of sodium hydride leads to the fully protected synthon 3 in good yields.Deprotection by sodium hydroxide and hydrogenolysis yields almost quantitively the key substance 5.