O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

Base Information

Chemical Name:O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate
CAS No.:1332626-57-9
Molecular Formula:C₂₇H₃₈FNO₃S₂
Molecular Weight:507.734
Hs Code.:

Synonyms:O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

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Chemical Property of O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

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Technology Process of O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

There total 3 articles about O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-15-0,12122-00-8
carbon disulfide

: 1332626-55-7
(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

: 74-88-4
methyl iodide

: 1332626-57-9
O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

Guidance literature:: (2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol; With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

carbon disulfide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/ol2019828

Reference yield:

: 1332626-18-2
N,N-diallyl-3-bromo-5-fluoroaniline

: 1332626-57-9
O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere

1.2: 1 h / -78 - -20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

2.3: 0.25 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ol2019828

Reference yield:

: 134168-97-1
3-bromo-5-fluoroaniline

: 1332626-57-9
O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 1 h / -78 - -20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

3.3: 0.25 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol2019828