(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

Base Information

Chemical Name:(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol
CAS No.:1332626-55-7
Molecular Formula:C₂₅H₃₆FNO₃
Molecular Weight:417.564
Hs Code.:

Synonyms:(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

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Chemical Property of (2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

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Technology Process of (2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

There total 2 articles about (2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₂O₃

: 1332626-18-2
N,N-diallyl-3-bromo-5-fluoroaniline

: 1332626-55-7
(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

Guidance literature:: N,N-diallyl-3-bromo-5-fluoroaniline; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

C₁₃H₂₂O₃; In diethyl ether; hexane; at -78 - -20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol2019828

Reference yield:

: 134168-97-1
3-bromo-5-fluoroaniline

: 1332626-55-7
(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 1 h / -78 - -20 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol2019828

Reference yield:

: 75-15-0,12122-00-8
carbon disulfide

: 1332626-55-7
(2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol

: 74-88-4
methyl iodide

: 1332626-57-9
O-((2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl) S-methyl carbonodithioate

Guidance literature:: (2S,4S,5R,6S)-1-(3-(diallylamino)-5-fluorophenyl)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-ol; With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

carbon disulfide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/ol2019828