4-Oxazolecarboxamide,N-methoxy-N-methyl-(9CI)

Base Information

• Chemical Name: 4-Oxazolecarboxamide,N-methoxy-N-methyl-(9CI)
• CAS No.: 170486-48-3
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.13900
• Mol file: 170486-48-3.mol

Synonyms:4-oxazolyl-N-methyl-N-methoxy-carboxamide;

Chemical Property of 4-Oxazolecarboxamide,N-methoxy-N-methyl-(9CI)

Chemical Property:

• Boiling Point: 300.0±13.0 °C(Predicted)
• PKA: -1.90±0.10(Predicted)
• PSA: 55.57000
• Density: 1.228±0.06 g/cm3(Predicted)
• LogP: 0.30800

Purity/Quality:

Oxazole-4-carboxylic acid methoxymethylamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Oxazolecarboxamide,N-methoxy-N-methyl-(9CI)

There total 5 articles about 4-Oxazolecarboxamide,N-methoxy-N-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyloxazole-4-carboxamide (170486-48-3)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With dimethylaluminum chloride; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

oxazole-4-carboxylic acid ethyl ester; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja5043462

Reference yield: 33.0%

1,3-oxazole-4-carboxylic acid (23012-13-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyloxazole-4-carboxamide (170486-48-3)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; for 0.333333h;

Reference yield: 33.0%

Ν,Ο-dimethylhydroxylamine hydrochloride + 1,3-oxazole-4-carboxylic acid (23012-13-7) → N-methoxy-N-methyloxazole-4-carboxamide (170486-48-3)

Guidance literature:

1,3-oxazole-4-carboxylic acid; With benzotriazol-1-ol; for 0.166667h;

Ν,Ο-dimethylhydroxylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

upstream raw materials:

methyl 4.-oxazolecarboxylate

trimethylaluminum

oxazole-4-carboxylic acid ethyl ester

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

1-(oxazol-4-yl)ethanone

1,3-oxazole-4-carboxaldehyde