(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

Base Information

Chemical Name:(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine
CAS No.:865262-80-2
Molecular Formula:C₃₅H₄₀N₂O₂
Molecular Weight:520.715
Hs Code.:

Synonyms:(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

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Chemical Property of (2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

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Technology Process of (2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

There total 5 articles about (2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 865262-76-6
(2S,4aS,7R,8aR)-[2-(3-benzyl-4,4,7-trimethyl-octahydrobenzo[e][1,3]oxazin-2-yl)benzylidene]phenyl amine

: 110-00-9
furan

: 865262-80-2
(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

Guidance literature:: furan; With n-butyllithium; In tetrahydrofuran; at -78 - -30 ℃;

(2S,4aS,7R,8aR)-[2-(3-benzyl-4,4,7-trimethyl-octahydrobenzo[e][1,3]oxazin-2-yl)benzylidene]phenyl amine; In tetrahydrofuran; at -30 ℃; for 0.5h;
DOI:10.1021/jo0509509

Reference yield:

: 865262-74-4
(2S,4aS,7R,8aR)-N-benzyl-2-(o-formylphenyl)-4,4,7-trimethyl-octahydrobenzo[e][1,3]oxazine

: 865262-80-2
(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / CH₂Cl₂ / 20 °C

2.1: n-BuLi / tetrahydrofuran / -78 - -30 °C

2.2: 96 percent / tetrahydrofuran / 0.5 h / -30 °C

With n-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0509509

Reference yield:

: 115156-56-4
(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol

: 865262-80-2
(2S,2'S,4a'S,7'R,8a'R)-{[2-(N-benzyl-4',4',7'-trimethyl-octahydrobenzo[e][1,3]oxazin-2'-yl)phenyl]furan-2-yl-methyl}phenyl amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / benzene / 16 h / Heating

2.1: 98 percent / CH₂Cl₂ / 20 °C

3.1: n-BuLi / tetrahydrofuran / -78 - -30 °C

3.2: 96 percent / tetrahydrofuran / 0.5 h / -30 °C

With n-butyllithium; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo0509509