4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Base Information

Chemical Name:4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester
CAS No.:1393822-60-0
Molecular Formula:C₁₃H₁₂BrClO₂
Molecular Weight:315.594
Hs Code.:

Synonyms:4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

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Chemical Property of 4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

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Technology Process of 4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

There total 2 articles about 4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-bromo-p-chlorophenylacetyl chloride

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 1393822-60-0
4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol3018775

Reference yield:

: 52864-56-9
2-(2-bromo-4-chlorophenyl)acetic acid

: 1393822-60-0
4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; In dichloromethane; 2: |Wittig-Horner Reaction;
DOI:10.1021/ol3018775

Reference yield: 82.0%

: 1393822-60-0
4-(2-bromo-4-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

: 62-53-3
aniline

: 1393822-48-4
2-(6-chloro-1-phenyl-1H-indol-2-yl)propionic acid ethyl ester

Guidance literature:: With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; for 6h; Inert atmosphere; Reflux;
DOI:10.1021/ol3018775