1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Base Information

Chemical Name:1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole
CAS No.:1396123-90-2
Molecular Formula:C₂₀H₂₆BF₃N₂O₂
Molecular Weight:394.245
Hs Code.:

Synonyms:1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

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Chemical Property of 1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

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Technology Process of 1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

There total 15 articles about 1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1396123-83-3
3-phenyl-4-(trifluoromethyl)-1,2,3-λ⁵-oxadiazol-3-ium-5-olate

: 159087-40-8
2-hex-1-ynyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 957188-42-0
1-phenyl-3-n-butyl-5-trifluoromethyl-1H-pyrazole

: 1396123-90-2
1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: In 1,2-dichloro-benzene; at 140 ℃; for 72h; Sealed tube;
DOI:10.1021/ol3021918

Reference yield: 55.0%

: 1396123-83-3
3-phenyl-4-(trifluoromethyl)-1,2,3-λ⁵-oxadiazol-3-ium-5-olate

: 159087-40-8
2-hex-1-ynyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1396123-90-2
1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: In 1,2-dichloro-benzene; at 140 ℃; for 72h; regioselective reaction; Sealed tube;
DOI:10.1021/jo400381a

Reference yield:

: 622-37-7
Phenyl azide

: 957188-42-0
1-phenyl-3-n-butyl-5-trifluoromethyl-1H-pyrazole

: 1396123-90-2
1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 2 h / 20 °C

2: toluene / 2 h / 20 °C

3: lithium iodide / ethyl acetate / 4 h / Reflux

4: isopentyl nitrite / 1,2-dimethoxyethane / 5 h / 20 °C

5: trifluoroacetic anhydride / dichloromethane / 1 h / 0 - 20 °C

6: 1,2-dichloro-benzene / 72 h / 140 °C / Sealed tube

With trifluoroacetic anhydride; lithium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-benzene; toluene;
DOI:10.1021/ol3021918