2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

Base Information

Chemical Name:2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol
CAS No.:1580443-64-6
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

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Chemical Property of 2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

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Technology Process of 2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

There total 5 articles about 2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 13349-82-1
1-[2-(2-hydroxyethoxy)ethyl]piperazine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 120402-34-8
2-benzyl-5-hydroxybenzofuran

: 1580443-64-6
2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

Guidance literature:: In ethanol; water; Reflux;
DOI:10.1016/j.ejmech.2013.12.020

Reference yield:

: 383159-30-6
(5-methoxybenzofuran-2-yl)(phenyl)methanone

: 1580443-64-6
2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: chloro-trimethyl-silane; sodium cyanoborohydride / acetonitrile / 60 h / 20 °C

2: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

3: ethanol; water / Reflux

With chloro-trimethyl-silane; boron tribromide; sodium cyanoborohydride; In ethanol; dichloromethane; water; acetonitrile; 3: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.12.020

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1580443-64-6
2-benzyl-4-((4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)methyl)benzofuran-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / butanone / 5 h / Reflux

2: chloro-trimethyl-silane; sodium cyanoborohydride / acetonitrile / 60 h / 20 °C

3: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

4: ethanol; water / Reflux

With chloro-trimethyl-silane; boron tribromide; sodium cyanoborohydride; potassium carbonate; In ethanol; dichloromethane; water; acetonitrile; butanone; 4: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.12.020