ethyl 2-methoxy-2-methyl-3-phenylpropionate

Base Information

• Chemical Name: ethyl 2-methoxy-2-methyl-3-phenylpropionate
• CAS No.: 343986-59-4
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 343986-59-4.mol

Synonyms:ethyl 2-methoxy-2-methyl-3-phenylpropionate

Chemical Property of ethyl 2-methoxy-2-methyl-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methoxy-2-methyl-3-phenylpropionate

There total 2 articles about ethyl 2-methoxy-2-methyl-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl (S)-2-methoxypropanoate (41918-08-5) + benzyl bromide (100-39-0) → ethyl 2-methoxy-2-methyl-3-phenylpropionate (343986-59-4)

Guidance literature:

ethyl (S)-2-methoxypropanoate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; hexane; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/ja0042938

Reference yield:

(S)-Ethyl lactate (687-47-8) → ethyl 2-methoxy-2-methyl-3-phenylpropionate (343986-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: 60 percent / tetrahydrofuran / 12 h / 20 °C

2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 83 percent / tetrahydrofuran; hexane / 16 h / 20 °C

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane;

DOI:10.1021/ja0042938

Reference yield: 96.0%

ethyl 2-methoxy-2-methyl-3-phenylpropionate (343986-59-4) → 2-methoxy-2-methyl-3-phenylpropionic acid (343986-60-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/ja0042938

upstream raw materials:

ethyl (S)-2-methoxypropanoate

benzyl bromide

(S)-Ethyl lactate

Downstream raw materials:

2-methoxy-2-methyl-3-phenylpropionic acid

(2-methoxyprop-1-en-1-yl)benzene

(2-methoxyprop-1-en-1-yl)benzene

3-bromo-2-methoxy-2-methyl-3-phenyl-propionic acid