ethyl (2S)-2-methoxypropanoate

Base Information

• Chemical Name: ethyl (2S)-2-methoxypropanoate
• CAS No.: 41918-08-5
• Molecular Formula: C6H12 O3
• Molecular Weight: 132.159
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID20962050
• Nikkaji Number: J56.996H
• Wikidata: Q82943633
• Mol file: 41918-08-5.mol

Synonyms:ethyl (2S)-2-methoxypropanoate;41918-08-5;ethyl (s)-(-)-2-methoxypropionate;Ethyl(S)-(-)-2-methoxypropionate;(S)-Ethyl 2-methoxypropanoate;(2S)-2-Methoxypropanoic acid ethyl ester;SCHEMBL8223259;ethyl ((S)-2-methoxypropanoate;DTXSID20962050;MFCD01632590;AKOS006240445;[S,(?)]-2-Methoxypropionic acid ethyl ester

Chemical Property of ethyl (2S)-2-methoxypropanoate

Chemical Property:

• Vapor Pressure: 2.44mmHg at 25°C
• Boiling Point: 160°C at 760 mmHg
• Flash Point: 49.9°C
• PSA: 35.53000
• Density: 0.959g/cm³
• LogP: 0.58440
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 132.078644241
• Heavy Atom Count: 9
• Complexity: 90.3

Purity/Quality:

99% ^*data from raw suppliers

O-Methyl-L-lacticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)OC
• Isomeric SMILES: CCOC(=O)[C@H](C)OC
• Uses: O-Methyl-L-lactic Acid Ethyl Ester (cas# 41918-08-5) is a compound useful in organic synthesis.

Technology Process of ethyl (2S)-2-methoxypropanoate

There total 8 articles about ethyl (2S)-2-methoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-Ethyl lactate (687-47-8) + methyl iodide (74-88-4) → ethyl (S)-2-methoxypropanoate (41918-08-5)

Guidance literature:

With silver(l) oxide; In acetonitrile; for 5h; Heating;

DOI:10.1021/jo980582r

Reference yield: 48.0%

(S)-Ethyl lactate (687-47-8) → ethyl (S)-2-methoxypropanoate (41918-08-5)

Guidance literature:

(S)-Ethyl lactate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

methyl halide; In tetrahydrofuran; at 0 - 20 ℃; for 12.75h;

DOI:10.1039/b501346c

Reference yield:

(S)-Ethyl lactate (687-47-8) + methyl iodide (74-88-4) → ethyl (S)-2-methoxypropanoate (41918-08-5) + (2R)-Ethyl 2-methoxypropanoate (40105-20-2)

Guidance literature:

With sodium; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, 2.) from -78 deg C to RT;

DOI:10.1021/ja00003a028

upstream raw materials:

(S)-Ethyl lactate

methyl iodide

ethyl 2-hydroxypropionate

dimethyl sulfate

Downstream raw materials:

2-methoxypropionic acid

ethyl 2-methoxy-2-methyl-3-phenylpropionate

triphenyltin ethoxide

(-)-(S)-2-methoxy-propionyl chloride