(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

Base Information

Chemical Name:(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate
CAS No.:936482-24-5
Molecular Formula:C₂₃H₂₁F₃N₂O₇
Molecular Weight:494.424
Hs Code.:

Synonyms:(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

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Chemical Property of (4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

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Technology Process of (4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

There total 3 articles about (4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 936482-23-4
(R)-diethyl 2-(2-nitro-1-(2,4,5-trifluorophenyl)ethyl)malonate

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 936482-24-5
(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

Guidance literature:: In ethanol; at 85 ℃; for 4h;
DOI:10.1021/jm061436d

Reference yield:

: 915100-66-2
(E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene

: 936482-24-5
(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: C₂-symmetric bisoxazoline ligand; Mg(OTf)2*4H₂O; N-methyl morpholine / CHCl₃ / 20 °C

2: 94 percent / ethanol / 4 h / 85 °C

With 4-methyl-morpholine; magnesium triflate; In ethanol; chloroform; 1: Michael addition;
DOI:10.1021/jm061436d

Reference yield:

: 105-53-3
diethyl malonate

: 936482-24-5
(4R,5R)-ethyl 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-nitro-2-oxo-4-(2,4,5-trifluorophenyl)-piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: C₂-symmetric bisoxazoline ligand; Mg(OTf)2*4H₂O; N-methyl morpholine / CHCl₃ / 20 °C

2: 94 percent / ethanol / 4 h / 85 °C

With 4-methyl-morpholine; magnesium triflate; In ethanol; chloroform; 1: Michael addition;
DOI:10.1021/jm061436d