N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide
CAS No.:817160-10-4
Molecular Formula:C₁₉H₂₆N₂O₅SSi
Molecular Weight:422.577
Hs Code.:

Synonyms:N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

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Technology Process of N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

There total 1 articles about N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 68847-33-6
2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 817160-10-4
N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

Guidance literature:: With TEA; In dichloromethane; at 30 ℃; for 24h;
DOI:10.1016/j.tet.2004.09.072

Reference yield: 62.0%

: 30934-97-5
2,2-dimethoxyethanol

: 817160-10-4
N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

: 817160-12-6
N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -20 - 30 ℃; for 21h;
DOI:10.1016/j.tet.2004.09.072

Reference yield:

: 817160-10-4
N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-nitrobenzenesulfonamide

: 817160-21-7
1-benzoyl-3-methoxy-1,2,3,5-tetrahydro-4,1-benzoxazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / PPh₃; DIAD / tetrahydrofuran / 21 h / -20 - 30 °C

2: 83 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

3: 100 percent / BF₃*OEt₂ / diethyl ether

4: 98 percent / K₂CO₃; PhSH / dimethylformamide / 1 h / 20 °C

5: 100 percent / TEA / CH₂Cl₂ / 3 h / 0 - 5 °C

With di-isopropyl azodicarboxylate; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; thiophenol; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/j.tet.2004.09.072