2,2-Dimethoxyethanol

Base Information

• Chemical Name: 2,2-Dimethoxyethanol
• CAS No.: 30934-97-5
• Molecular Formula: C4H10O3
• Molecular Weight: 106.122
• Hs Code.: 2911000000
• European Community (EC) Number: 250-398-7
• UNII: U5USE33Y47
• DSSTox Substance ID: DTXSID10184921
• Nikkaji Number: J287.414H
• Wikidata: Q27290722
• Mol file: 30934-97-5.mol

Synonyms:2,2-Dimethoxyethanol;30934-97-5;Glycolaldehyde dimethyl acetal;Ethanol, 2,2-dimethoxy-;2,2-dimethoxyethan-1-ol;2,2-DIMETHOXY ETHANOL;2,2-Dimethoxy-ethanol;Hydroxyacetaldehyde Dimethyl Acetal;UNII-U5USE33Y47;U5USE33Y47;EINECS 250-398-7;MFCD00051799;Hydroxyacetaldehyde Dimethylacetal;Cbz-DL-Asp-OH;SCHEMBL175826;DTXSID10184921;2-hydroxyacetaldehyde dimethyl acetal;AKOS009159043;GLYCOLALDEHYDE, DIMETHYL ACETAL;CS-W011294;SB84093;AS-33339;SY122147;FT-0609248;EN300-107234;A820660;Q27290722

Chemical Property of 2,2-Dimethoxyethanol

Chemical Property:

• Vapor Pressure: 1.85mmHg at 25°C
• Melting Point: <-76°C
• Refractive Index: 1.4130
• Boiling Point: 146.1 °C at 760 mmHg
• PKA: 14.83±0.10(Predicted)
• Flash Point: 42.2 °C
• PSA: 38.69000
• Density: 1.009 g/cm³
• LogP: -0.40240
• Water Solubility.: Miscible with water.
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 106.062994177
• Heavy Atom Count: 7
• Complexity: 33.9

Purity/Quality:

99.9% ^*data from raw suppliers

GlycolaldehydeDimethylAcetal ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(CO)OC
• Uses: Glycolaldehyde dimethyl acetal is used in the preparation of aceto- xyacetaldehyde dimethyl acetal by reacting with acetic anhydride.

Technology Process of 2,2-Dimethoxyethanol

There total 31 articles about 2,2-Dimethoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

glycolaldehyde dimer (23147-58-2,110822-84-9,110822-85-0,77431-49-3) + methanol (67-56-1) → 2,2-dimethoxyethanol (30934-97-5)

Guidance literature:

aminopropylated Silica-Gel hydrochloride (APSG*HCl) resin; for 15h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91796-X

Reference yield: 68.0%

methanol (67-56-1) + Methyl formate (107-31-3) → 2,2-dimethoxyethanol (30934-97-5)

Guidance literature:

With titanium tetrachloride; for 3h; Irradiation;

DOI:10.1246/cl.1981.1469

Reference yield: 37.0%

methanol (67-56-1) + formic acid (64-18-6) → 2,2-dimethoxyethanol (30934-97-5)

Guidance literature:

With titanium tetrachloride; for 3h; Irradiation;

DOI:10.1246/cl.1981.1469

upstream raw materials:

methoxyoxirane

methanol

2-benzyloxy-1,1-dimethoxyethane

Glycolaldehyde

Downstream raw materials:

N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-N-(2,2-dimethoxyethyl)-4-nitrobenzenesulfonamide

N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide

methyl lactate

Refernces

• 1、 Hou, Wenrong,Yan, Yueer,Li, Gang,Zhan, Yulu,Feng, Lei,Zhang, Ruohong,Hua Li, Zhen,Zhang, Yahong,Tang, Yi. "Catalysis and Stability Effect of Solvent Alcohol on the C6 Aldose Conversion toward Tetrose". . p. 4182 - 4188. Retrieved 2019/09/12.
• 2、 Elliot,Andersen,Tolborg,Meier,Sádaba,Daugaard,Taarning. "Synthesis of a novel polyester building block from pentoses by tin-containing silicates". . p. 985 - 996. Retrieved 2017/01/13.