N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

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Chemical Name:N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide
CAS No.:1312929-26-2
Molecular Formula:C₂₆H₂₄N₈O₃
Molecular Weight:496.528
Hs Code.:

Synonyms:N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

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Technology Process of N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

There total 8 articles about N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1312929-35-3
2-(pyrrolidin-2-yl)pyridine hydrochloride

: 1312929-46-6
3-(2-chlorofuro[3,2-d]pyrimidin-4-ylamino)-N-(3-methoxyphenyl)-1H-pyrazole-5-carboxamide

: 1312929-26-2
N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 3h; microwave irradiation;

Reference yield:

: 956034-07-4
2,4-dichloro-furo[3,2-d]pyrimidine

: 1312929-26-2
N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylamine / isopropyl alcohol / 48 h / Reflux

2: sodium hydroxide; water / ethanol / 48 h / Reflux

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 200 °C / microwave irradiation

With water; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 956034-03-0
methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate

: 1312929-26-2
N-(3-methoxyphenyl)-3-(2-(2-(pyridin-2-yl)pyrrolidin-1-yl)furo[3,2-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.1: dichloromethane / 0.75 h / 0 °C

2.2: 1 h / 20 °C

2.3: pH 8

3.1: sodium hydroxide; water / 5 h / Reflux

3.2: pH 4 - 5

4.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 130 °C

5.1: diisopropylamine / isopropyl alcohol / 48 h / Reflux

6.1: sodium hydroxide; water / ethanol / 48 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 200 °C / microwave irradiation

With water; N,N-dimethyl-aniline; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;