(2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester

Base Information

• Chemical Name: (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester
• CAS No.: 526223-54-1
• Molecular Formula: C₃₈H₄₄N₂O₉Si
• Molecular Weight: 700.861
• Mol file: 526223-54-1.mol

Synonyms:(2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester

Chemical Property of (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester

There total 1 articles about (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{4-[2-tert-butoxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester → (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester (526223-54-1)

Guidance literature:

With silica gel; In toluene; at 110 ℃; for 1.5h;

DOI:10.1016/S0960-894X(02)00877-6

Reference yield: 73.0%

quinoline-3-carboxylic acid (6480-68-8) + (S)-pyrrolidin-2-carboxylic acid dimethylamide (29802-22-0,433980-61-1) + (S)-acetylproline (68-95-1) + (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester (526223-54-1) → Quinoline-3-carboxylic acid ((S)-2-{4-[(3S,5S)-1-((S)-1-acetyl-pyrrolidine-2-carbonyl)-5-((S)-2-dimethylcarbamoyl-pyrrolidine-1-carbonyl)-pyrrolidin-3-yloxy]-phenyl}-1-carbamoyl-ethyl)-amide

Guidance literature:

Multistep reaction;

DOI:10.1016/S0960-894X(02)00877-6

Reference yield:

2-Ethylbutanoic acid (88-09-5) + quinoline-3-carboxylic acid (6480-68-8) + Di-n-amylamine (2050-92-2) + (2S,4S)-4-{4-[(S)-2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-allyl ester 2-(2-trimethylsilanyl-ethyl) ester (526223-54-1) → (2S,4S)-4-{4-[(S)-2-Carbamoyl-2-(2-ethyl-butyrylamino)-ethyl]-phenoxy}-1-(quinoline-3-carbonyl)-pyrrolidine-2-carboxylic acid dipentylamide

Guidance literature:

Multistep reaction;

DOI:10.1016/S0960-894X(02)00877-6