2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

Base Information

Chemical Name:2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate
CAS No.:1427198-14-8
Molecular Formula:C₂₃H₂₇N₅O₅
Molecular Weight:453.498
Hs Code.:

Synonyms:2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

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Chemical Property of 2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

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Technology Process of 2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

There total 9 articles about 2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 590-36-3
2-methylpentan-2-ol

: 38377-38-7
4-fluorophenyl chloroformate

: 1427195-83-2
3-[(Z)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one

: 1427198-14-8
2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

Guidance literature:: 4-fluorophenyl chloroformate; 3-[(Z)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one; With pyridine; In acetonitrile; at 20 ℃; for 2h;

2-methylpentan-2-ol; In acetonitrile; for 5h; Reflux;

Reference yield:

: 1427201-43-1
tert-butyl {6-[({[(Z)-cyano(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

: 1427198-14-8
2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 12 h / Reflux

2.1: hydroxylamine hydrochloride; potassium carbonate / isopropyl alcohol; water / 6 h / 80 °C

3.1: N,N-dimethyl-formamide / 6.5 h / 20 - 80 °C

4.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 20 °C

5.1: pyridine / acetonitrile / 2 h / 20 °C

5.2: 5 h / Reflux

With pyridine; hydroxylamine hydrochloride; potassium carbonate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1427201-30-6
(1Z,2Z)-2-{[(6-aminopyridin-2-yl)methoxy]imino}-N'-hydroxy-2-phenylethanimidamide

: 1427198-14-8
2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 6.5 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 20 °C

3.1: pyridine / acetonitrile / 2 h / 20 °C

3.2: 5 h / Reflux

With pyridine; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;