(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Base Information

Chemical Name:(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid
CAS No.:1352082-75-7
Molecular Formula:C₃₄H₃₄N₄O₄
Molecular Weight:562.668
Hs Code.:

Synonyms:(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Suppliers and Price of (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

There total 14 articles about (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1352082-74-6
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

: 1352082-75-7
(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate; With water; lithium hydroxide; In 1,4-dioxane; isopropyl alcohol; at 20 ℃; for 18h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 120728-10-1
1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid

: 1352082-75-7
(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2.1: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide / isopropyl alcohol; 1,4-dioxane / 18 h / 20 °C

5.2: pH 1

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1352082-75-7
(2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2.1: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: water; lithium hydroxide / isopropyl alcohol; 1,4-dioxane / 18 h / 20 °C

5.2: pH 1

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;