ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Base Information

Chemical Name:ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate
CAS No.:1352082-74-6
Molecular Formula:C₃₆H₃₈N₄O₄
Molecular Weight:590.722
Hs Code.:

Synonyms:ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

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Chemical Property of ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

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Technology Process of ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

There total 12 articles about ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 863578-93-2
ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

: 1352082-73-5
3-cyclohexyl-2-phenyl-2H-indazole-6-carboxylic acid

: 1352082-74-6
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 120728-10-1
1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid

: 1352082-74-6
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1352082-74-6
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: triethylamine / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 15 h / 85 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;